authentic, typed letter signed (TLS) by Dr. William J. Mayo, the world-renowned surgeon and co-founder of the Mayo Clinic. Dated January 2, 1923, on his personalized Rochester, Minnesota stationery, this fascinating piece of correspondence is addressed directly to Mrs. Carl Koller, the wife of the pioneering ophthalmologist Dr. Carl Koller who discovered local anesthesia. In the letter, Dr. Mayo warmly thanks Mrs. Koller for her yearly holiday message and a gifted \"Calendar of Cheer,\" while extending his kindest new year wishes to the couple. The item features a beautifully crisp, dark fountain pen signature (W. J. Mayo) at the bottom right. Included with the letter is the original matching envelope, complete with a bold \"Rochester, MINN. JAN 2 1923\" postmark (ENVELOPE HAS HUGE TEAR)........ Code JSB 341

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